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Article
Peer Reviewed

Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019

Li, Yijia;
Harrison, Linda J;
Chew, Kara W;
Currier, Judy S;
Wohl, David A;
Daar, Eric S;
Evering, Teresa H;
Wu, Ryan;
Giganti, Mark;
Ritz, Justin;
Javan, Arzhang Cyrus;
Coombs, Robert W;
Moser, Carlee;
Hughes, Michael D;
Eron, Joseph J;
Smith, Davey M;
Li, Jonathan Z

UC San Diego Previously Published Works (2023)

Acute Coronavirus Disease 2019 symptoms limit daily activities, but little is known about its association with severe acute respiratory syndrome coronavirus 2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal RNA levels and detectable plasma RNA were associated with delayed symptom improvement. Clinical Trials Registration. https://clinicaltrials.gov/ct2/show/NCT04518410.

Cover page: Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019