Despite the lasting aversion many hold towards rats and mice owing to historical associations with diseases such as the plague, there exists a growing consensus among researchers advocating for a reappraisal of these creatures. A noticeable trend is emerging in Western Europe, wherein rodents are increasingly viewed as urban neighbors, challenging the prevailing negative perceptions. To explain the ongoing shift, we use examples from medicine, popular culture, science, and exhibitions. The recognition of rats and mice as sentient and intelligent beings necessitates human stewardship in the context of urban coexistence. We conclude that understanding the ecology and behavior of rats and mice in urban environments, as well as human behavior change, is a prerequisite for achieving harmonious urban coexistence.