Maintaining accurate measurements ofsedation in the ICU are essential forpatient comfort, safety, and clinicaloutcomes. Current clinical sedation scales, such asthe Richmond Agitation-Sedation Scale(RASS) suffer from subjectivity and poorinter-rater reliability. Processed EEGs (pEEGs) may providea more objective and reliable alternativeto assess depth of sedation in ICUpatients. In this study, we conducted a systematicliterature review on 3 major pEEGs(Masimo Sedline, Bispectral Index, andNarcotrend) and their correlation withgold standard clinical sedation scales.