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Article
Peer Reviewed

Remdesivir for the prevention of invasive mechanical ventilation or death in COVID-19 - A post-hoc analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data

Paules, Catharine I;
Gallagher, Shannon K;
Rapaka, Rekha R;
Davey, Richard T;
Doernberg, Sarah B;
Grossberg, Robert;
Hynes, Noreen A;
Ponce, Philip;
Short, William R;
Voell, Jocelyn;
Wang, Jing;
Yang, Otto O;
Wolfe, Cameron R;
Lye, David C;
Dodd, Lori E;
Benson, Constance A

UCLA Previously Published Works (2022)

This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.

Cover page: Remdesivir for the prevention of invasive mechanical ventilation or death in COVID-19 - A post-hoc analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data