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Scholarly Works (1 results)

Article
Peer Reviewed

Tuning through-space interactions via the secondary coordination sphere of an artificial metalloenzyme leads to enhanced Rh( iii )-catalysis

Hassan, Isra S;
Fuller, Jack T;
Dippon, Vanessa N;
Ta, Angeline N;
Danneman, Michael W;
McNaughton, Brian R;
Alexandrova, Anastassia N;
Rovis, Tomislav

UCLA Previously Published Works (2022)

We report computationally-guided protein engineering of monomeric streptavidin Rh(iii) artificial metalloenzyme to enhance catalysis of the enantioselective coupling of acrylamide hydroxamate esters and styrenes. Increased TON correlates with calculated distances between the Rh(iii) metal and surrounding residues, underscoring an artificial metalloenzyme's propensity for additional control in metal-catalyzed transformations by through-space interactions.

Cover page: Tuning through-space interactions via the secondary coordination sphere of an artificial metalloenzyme leads to enhanced Rh( iii )-catalysis