This study investigates the connection between antimicrobial resistance (AMR) and climate change across diverse global regions. The study focuses on Mexico, Southeast Asia, and Canada. By analyzing how regional climatic conditions such as temperature, humidity, and seasonal weather patterns influence AMR dynamics, the research can address the critical question of how to tackle AMR. Based on the global escalation of AMR and its profound implications for public health, our study is vital in highlighting the necessity for integrated climate change mitigation strategies within AMR management. The findings emphasize the urgency of surveillance, targeted research, and enforcing strict antimicrobial stewardship to counteract the rising threat of AMR, thereby informing more effective global health responses and policy-making in an era of significant environmental change.