In civil, mechanical, and aerospace structures, full-field measurement has become necessary to estimate the precise location of precise damage and controlling purposes. Conventional full-field sensing requires dense installation of contact-based sensors, which is uneconomical and mostly impractical in a real-life scenario. Recent developments in computer vision-based measurement instruments have the ability to measure full-field responses, but implementation for long-term sensing could be impractical and sometimes uneconomical. To circumvent this issue, in this paper, we propose a technique to accurately estimate the full-field responses of the structural system from a few contact/non-contact sensors randomly placed on the system. We adopt the Compressive Sensing technique in the spatial domain to estimate the full-field spatial vibration profile from the few actual sensors placed on the structure for a particular time instant, and executing this procedure repeatedly for all the temporal instances will result in real-time estimation of full-field response. The basis function in the Compressive Sensing framework is obtained from the closed-form solution of the generalized partial differential equation of the system; hence, partial knowledge of the system/model dynamics is needed, which makes this framework physics-guided. The accuracy of reconstruction in the proposed full-field sensing method demonstrates significant potential in the domain of health monitoring and control of civil, mechanical, and aerospace engineering systems.