Efforts have always been deployed to surpass limitations in human cognitive abilities to enhance aspects such as task accuracy, work effectiveness and error management. Cognitive enhancement is a field aiming at improving human cognition in order to overcome those limitations. It bears important interest from the human factors community given its potential for reducing errors in complex operational environments. Yet, cognitive enhancement strategies are rarely used outside the lab and practical applications are scarce. The current paper presents a brief summary of the literature on human cognitive enhancement and discusses key operational applications of the main methods reported in this field. Using a human factors perspective, the paper also outlines how such techniques could be integrated into decision-support tools to support operators facing cognitive challenges in complex operational domains, including those experiencing functional limitations preventing them to contribute to the workforce.