During 1990 and 1991 we conducted safety, efficacy and clinical trials required to register alpha-chloralose (A-C) for capturing nuisance waterfowl and pigeons with the U.S. Food and Drug Administration (FDA). We determined the Most Effective Dose (MED) to be 30 and 60 mg of A-C/kg of body weight for capturing waterfowl and pigeons, respectively. We conducted 11 field trials in 4 states, capturing 587 waterfowl and 1,370 pigeons with 8% mortality for ducks, 0% for geese, and 6% for pigeons. We submitted a New Animal Drug Application to FDA in October 1991 and anticipate registration in 1992.