The increased mobility in the Mediterranean area is strictly connected with the events of 1989. When Eastern Europe’s ideological borders were demolished, the Southern Italian region Apulia was relocated on the Mediterranean map, and from being on the periphery of the Adriatic, unexpectedly it came to occupy a new, centered place. This geographical repositioning inevitably turned Apulia into a free western frontier and an open shore for waves of migrants. This essay discusses the historical events, international political factors, and global economic interests that determined the new destiny of the region. Since the spirit of the frontier has always inspired writers and filmmakers, it was no accident that Italian directors have chosen Apulia as the set and setting for their new, human odysseys and modern heroes. In order to explain the reasons for the rich film production in Apulia, first, this essay presents the directors whose works contribute to the genre of films on migration and transit to and fro the different shores of the Mediterranean; and second, it analyzes a selection of films by Apulian directors portraying universal, human dramas through local, private stories.