In this dissertation, I report my work on making two-dimensional van der Waals heterostructure devices. Chapter one introduces the main concepts of the band structure of graphene and the quantum Hall effect. These are the necessary theoretical foundation to understand transport experiment results in the following chapters. Chapter two includes the device fabrication techniques and recipes for fabrication. In Chapter three, I illustrate different characterization methods to study the properties of van der Waals heterostructure devices. Chapter four presents more detailed work on transport measurements of twisted bilayer graphene devices.