In this review the well-being of post-sexual reassignment individuals will be discussed. Gender dysphoria (GD) and sexual reassignment surgery (SRS) continues to be a research process for the scientific community on evaluating the health statuses of transitioned individuals. Though researchers consider this subject in its primitive stage of investigation, the literature available gives ideas in assessing whether these sexual reassignment procedures work for gender dysphoric individuals. There is a diverse amount of material on GD and SRS that detail both similar and differing results depending on the type of methodologies used by researchers. Reviewing the style of research, methods, and results within studies can bring more knowledge and spring new ideas to form better conclusions on the health statuses of individuals diagnosed with gender dysphoria and their post-operative self.