In the last decade, Richardson’s ground squirrel populations have reached epidemic levels in western Canada. A review of socio-economic conditions and field research findings suggests that such outbreaks are the result of many factors working synergistically on ground squirrel population dynamics and dispersal: 1) drought conditions, 2) poor grassland management, 3) low cattle prices due to bovine spongiform encephalopathy, 4) inefficient rodenticides, 5) loss of predators, and 6) loss of family-size operations to large-scale landowners. In the light of recent outbreaks experienced in western Canada, we now know that the control of Richardson’s ground squirrel populations requires a long-term management program, integrating sustainable grassland management techniques with an effective conservation of mammalian and avian predators, and the sensible use of effective rodenticides. The success of such a multi-faceted management program will depend on the establishment of an effective education program, the institution of incentive programs for a better management of grassland ecosystems, the implementation and enforcement of rules to better monitor the production and distribution of effective poisons, and minimizing excessive use by producers.