Contrast-Induced Nephropathy (CIN) is the third leading cause of kidney failure in theworld today (Krasinski, 2020, p.274). The condition develops in patients that receive iodinatedcontrast media (ICM) which is a dye that helps visualize the veins and arteries during coronaryangiograms and computed tomography (CT) scans. CIN is defined as a deterioration of thekidney due to the injection of contrast administration leading to kidney failure. Current CINliterature lacks fundamental understanding of how current hydration methods affect thelikelihood of this condition manifesting itself. The team sought to study this condition using ahydration protocol where 500 mL of normal saline was administered pre- and post-catheterization. Our main method of measurement was serum creatinine (sCr) which is theamount of creatinine found in the blood. The primary question of this study was to determinewhether patients with high-risk factors would be less likely to develop Post-Contrast AcuteKidney Injury (PC-AKI). A rise of the creatinine level of ≥0.30 mg/dL within 48 to 72 hourspost-procedure is the definition used in this observational study for development of PC-AKI.Based on trends found within the post-procedure time span, sCr levels lowered significantly,indicating a reduction in likelihood of patients developing PC-AKI. The decreasing sCr trendssuggested an appreciable difference after a two-sample t test was performed. Applying theseinsights show that elevated saline volume given potentially decreases future risk of PC-AKI.