Oriented cell division is crucial for tissue patterning and organ development in plants due to the presence of rigid cell walls surrounding plant cells. However, to date, only a limited number of factors have been identified that mark cell division sites and/or orient the division plane. Here, we show that IRK (INFLORESCENCE AND ROOT APICES RECEPTOR KINASE), a leucine-rich repeat (LRR) containing receptor-like kinase (LRR-RLK), functions in root endodermal cell division orientation in A. thaliana. We report the identification of radial askew (RA) division, a novel division orientation defect in irk-4, which generates prism-shaped daughter cells at the endodermal cell periphery. We propose that polar accumulation of IRK to the outer plasma membrane domain restricts the establishment of misoriented division planes. Additionally, we have completed our study on PXC2 (PXY/TDR CORRELATED 2), an LRR-RLK, closely related to IRK. We show that loss of PXC2 functions in pxc2-3 results in an enlarged root stele area, without affecting endodermal cell division. Intriguingly, simultaneous loss of IRK and PXC2 functions in irk-4 pxc2-3 mutants exacerbates endodermal cell division defects and stele area phenotypes, suggesting they are functionally redundant. Furthermore, overexpression of PXC2 leads to severe plant growth abnormalities including shorter primary roots, and I hypothesize that excess PXC2 accumulation triggers a stress response that restricts plant growth. Moreover, we jointly characterized the functions of a novel long noncoding RNA (lncRNA) CARMA, which is associated with PXC2 in. A. thaliana. Unlike PXC2, overexpression of CARMA leads to enlarged root stele area. Our results suggest CARMA suppresses PXC2 promoter activity in a tissue-specific manner, and I hypothesize that suppression of PXC2 expression by CARMA enables roots to modulate stele area based on physiological requirements. In summary, our study illustrates how two closely related LRR-RLKs function redundantly to maintain root stele area and restrict endodermal cell division and properly orient the cell division plane. We also demonstrate how a novel lncRNA suppresses expression of its neighboring gene in a tissue-specific manner to uphold root homeostasis. These discoveries expand our current comprehension of LRR-RLK biology and the roles of plant specific lncRNA in root development.