In this dissertation, interference suppression techniques and applications will be presented for cellular networks with direct-sequence (DS) CDMA and mobile ad hoc networks with frequency-hopped (FH) CDMA. The first part of the dissertation focuses on three novel finger placement designs that effectively equalize the DS-CDMA multipath downlink channel to restore code orthogonality and consequently suppress multiple-access interference. For typical multipath channel models, the proposed schemes may significantly outperform the uniformly spaced tapped-delay -line equalizer with much less fingers/taps. In addition, analytic insight into the effect of the finger number and the smoothness of the chip pulse are obtained. The second part of the dissertation considers mobile ad hoc networks with FH-CDMA, where error-correcting codes are employed with differential unitary space-time modulation. The use of multiple transmit antennas in FH-CDMA systems, to the best knowledge of the author, has not been proposed in previous literature. The proposed receiver performs decision-feedback demodulation, decision-aided adaptive estimation, and erasure-insertion decoding jointly to suppress arbitrary unknown interference without channel state information. The third part of the dissertation presents network performance analysis for FH-CDMA networks with the proposed transceiver. Information efficiency and transmission range optimization is investigated under realistic time-varying channel models, which extends previous studies based on static channels and/or simplistic physical layer models. Impacts of various design parameters and channel properties on the network performance are revealed. The results also provide guidance on optimizing the modulation and coding scheme from a network perspective