Current vehicle climate control systems are dramatically overpowered because they are designed to condition the cabin air mass in a specified period of time. A more effective and energy efficient objective is to directly achieve thermal comfort of the passengers. NREL is developing numerical and experimental tools to predict human thermal comfort in non-uniform transient thermal environments. These tools include a finite element model of human thermal physiology, a psychological model that predicts both local and global thermal comfort, and a high spatial resolution sweating thermal manikin for testing in actual vehicles.