- Boel, Judith A;
- de Bie, Rob MA;
- Schmand, Ben A;
- Dalrymple‐Alford, John C;
- Marras, Connie;
- Adler, Charles H;
- Goldman, Jennifer G;
- Tröster, Alexander I;
- Burn, David J;
- Litvan, Irene;
- Geurtsen, Gert J;
- Bernard, Bryan;
- Stebbins, Glenn;
- Filoteo, J Vincent;
- Weintraub, Daniel;
- Caviness, John N;
- Belden, Christine;
- Zabetian, Cyrus P;
- Cholerton, Brenna A;
- Huang, Xuemei;
- Eslinger, Paul J;
- Leverenz, James B;
- Duff‐Canning, Sarah;
- Farrer, Matt;
- Anderson, Tim J;
- Myall, Daniel J;
- Naismith, Sharon L;
- Lewis, Simon JG;
- Halliday, Glenda M;
- Wu, Ruey‐Meei;
- Williams‐Gray, Caroline H;
- Breen, David P;
- Barker, Roger A;
- Yarnall, Alison J;
- Klein, Martin;
- Mollenhauer, Brit;
- Trenkwalder, Claudia;
- Kulisevsky, Jaime;
- Pagonabarraga, Javier;
- Gasca‐Salas, Carmen;
- Rodriguez‐Oroz, Maria C;
- Junque, Carme;
- Segura, Barbara;
- Barone, Paolo;
- Santangelo, Gabriella;
- Cammisuli, Davide M;
- Biundo, Roberta;
- Antonini, Angelo;
- Weis, Luca;
- Pedersen, Kenn Freddy;
- Alves, Guido
Background
The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.Methods
The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD.Results
PD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C-statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II.Conclusion
MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI.