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Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

  • Author(s): Wong, Jason YY
  • Margolis, Helene G
  • Machiela, Mitchell
  • Zhou, Weiyin
  • Odden, Michelle C
  • Psaty, Bruce M
  • Robbins, John
  • Jones, Rena R
  • Rotter, Jerome I
  • Chanock, Stephen J
  • Rothman, Nathaniel
  • Lan, Qing
  • Lee, Jennifer S
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971001/
No data is associated with this publication.
Abstract

BACKGROUND:Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear. OBJECTIVE:We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY. METHODS:We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM10), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants' monthly residential exposure. mLOY was detected with standard methods using signal intensity (median log-R ratio (mLRR)) of the male-specific chromosome Y regions from Illumina array data. Linear regression models were used to evaluate relations between mean exposure in the prior year, age, smoking and continuous mLRR. RESULTS:Increased PM10 was associated with mLOY, namely decreased mLRR (p-trend = 0.03). Compared with the lowest tertile (≤28.5 μg/m3), the middle (28.5-31.0 μg/m3; β = -0.0044, p = 0.09) and highest (≥31 μg/m3; β = -0.0054, p = 0.04) tertiles had decreased mLRR, adjusted for age, clinic, race/cohort, smoking status and pack-years. Additionally, increasing age (β = -0.00035, p = 0.06) and smoking pack-years (β = -0.00011, p = 1.4E-3) were associated with decreased mLRR, adjusted for each other and race/cohort. No significant associations were found for other pollutants. CONCLUSIONS:PM10 may increase leukocyte mLOY, a marker of genomic instability. The sample size was modest and replication is warranted.

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