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Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults
- Sheppard, David P;
- Weber, Erica;
- Casaletto, Kaitlin B;
- Avci, Gunes;
- Woods, Steven Paul;
- Grant, Igor;
- Atkinson, J Hampton;
- Ellis, Ronald J;
- McCutchan, J Allen;
- Marcotte, Thomas D;
- Marquie-Beck, Jennifer;
- Sherman, Melanie;
- Ellis, Ronald J;
- McCutchan, J Allen;
- Letendre, Scott;
- Capparelli, Edmund;
- Schrier, Rachel;
- Rosario, Debra;
- Heaton, Robert K;
- Cherner, Mariana;
- Iudicello, Jennifer E;
- Moore, David J;
- Morgan, Erin E;
- Dawson, Matthew;
- Jernigan, Terry;
- Fennema-Notestine, Christine;
- Archibald, Sarah L;
- Hesselink, John;
- Annese, Jacopo;
- Taylor, Michael J;
- Masliah, Eliezer;
- Achim, Cristian;
- Everall, Ian;
- Richman, Douglas;
- Smith, David M;
- McCutchan, J Allen;
- Achim, Cristian;
- Lipton, Stuart;
- Atkinson, J Hampton;
- Gamst, Anthony C;
- Cushman, Clint;
- Abramson, Ian;
- Vaida, Florin;
- Deutsch, Reena;
- Umlauf, Anya
- et al.
Published Web Location
https://doi.org/10.1016/j.jana.2016.03.006Abstract
Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.
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