Skip to main content
eScholarship
Open Access Publications from the University of California

Enantioselective synthesis of spliceostatin e and evaluation of biological activity

  • Author(s): Ghosh, AK
  • Veitschegger, AM
  • Sheri, VR
  • Effenberger, KA
  • Prichard, BE
  • Jurica, MS
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260646/
No data is associated with this publication.
Abstract

© 2014 American Chemical Society. An enantioselective total synthesis of spliceostatin E has been accomplished. The δ-lactone unit A was constructed from readily available (R)-glycidyl alcohol using a ring-closing olefin metathesis as the key reaction. A cross-metathesis of ring A containing δ-lactone and the functionalized tetrahydropyran B-ring provided spliceostatin E. Our biological evaluation of synthetic spliceostatin E revealed that it does not inhibit splicing in vitro and does not impact speckle morphology in cells. Spliceostatin E was reported to possess potent antitumor activity.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item