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Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County.

  • Author(s): Beymer, Matthew R
  • Kofron, Ryan M
  • Tseng, Chi-Hong
  • Bolan, Robert K
  • Flynn, Risa P
  • Sayles, Jennifer M
  • Perez, Mario J
  • Jordan, Wilbert C
  • Landovitz, Raphael J
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843554/
No data is associated with this publication.
Abstract

Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir). Approximately 64% of all PEP courses were followed for at least 12 weeks, and seven individuals seroconverted. Of the seven seroconversions, six had subsequent re-exposure. The low rate of PEP failure calls for expanded funding for PEP in other jurisdictions.

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