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Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.
- Lee, Mikyeong;
- Joehanes, Roby;
- McCartney, Daniel;
- Kho, Minjung;
- Hüls, Anke;
- Wyss, Annah;
- Liu, Chunyu;
- Walker, Rosie;
- R Kardia, Sharon;
- Wingo, Thomas;
- Burkholder, Adam;
- Ma, Jiantao;
- Campbell, Archie;
- Wingo, Aliza;
- Huan, Tianxiao;
- Sikdar, Sinjini;
- Keshawarz, Amena;
- Bennett, David;
- Smith, Jennifer;
- Evans, Kathryn;
- Levy, Daniel;
- London, Stephanie
Published Web Location
https://doi.org/10.2217/epi-2022-0353Abstract
Aim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: KIAA0226, CPLX2, TDRP, RNF38, TTC23 and GPR179. Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. Conclusion: This study identified DNA methylation related to opioid medication use in general populations. The results could inform the development of blood methylation biomarkers of opioid use.
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