Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
- Author(s): Lam, Max
- Trampush, Joey W
- Yu, Jin
- Knowles, Emma
- Djurovic, Srdjan
- Melle, Ingrid
- Sundet, Kjetil
- Christoforou, Andrea
- Reinvang, Ivar
- DeRosse, Pamela
- Lundervold, Astri J
- Steen, Vidar M
- Espeseth, Thomas
- Räikkönen, Katri
- Widen, Elisabeth
- Palotie, Aarno
- Eriksson, Johan G
- Giegling, Ina
- Konte, Bettina
- Roussos, Panos
- Giakoumaki, Stella
- Burdick, Katherine E
- Payton, Antony
- Ollier, William
- Chiba-Falek, Ornit
- Attix, Deborah K
- Need, Anna C
- Cirulli, Elizabeth T
- Voineskos, Aristotle N
- Stefanis, Nikos C
- Avramopoulos, Dimitrios
- Hatzimanolis, Alex
- Arking, Dan E
- Smyrnis, Nikolaos
- Bilder, Robert M
- Freimer, Nelson A
- Cannon, Tyrone D
- London, Edythe
- Poldrack, Russell A
- Sabb, Fred W
- Congdon, Eliza
- Conley, Emily Drabant
- Scult, Matthew A
- Dickinson, Dwight
- Straub, Richard E
- Donohoe, Gary
- Morris, Derek
- Corvin, Aiden
- Gill, Michael
- Hariri, Ahmad R
- Weinberger, Daniel R
- Pendleton, Neil
- Bitsios, Panos
- Rujescu, Dan
- Lahti, Jari
- Hellard, Stephanie Le
- Keller, Matthew C
- Andreassen, Ole A
- Glahn, David C
- Malhotra, Anil K
- Lencz, Todd
- et al.
Published Web Location
https://pubmed.ncbi.nlm.nih.gov/30001766/Abstract
Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88) presented a critique of our recently published paper in Cell Reports entitled 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets' (Lam et al., Cell Reports, Vol. 21, 2017, 2597-2613). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, 2018, 229-237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from 'inflation in the FDR [false discovery rate]', as suggested by Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88), and are not 'more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence'.
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