Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
- Author(s): Lam, Max;
- Trampush, Joey W;
- Yu, Jin;
- Knowles, Emma;
- Djurovic, Srdjan;
- Melle, Ingrid;
- Sundet, Kjetil;
- Christoforou, Andrea;
- Reinvang, Ivar;
- DeRosse, Pamela;
- Lundervold, Astri J;
- Steen, Vidar M;
- Espeseth, Thomas;
- Räikkönen, Katri;
- Widen, Elisabeth;
- Palotie, Aarno;
- Eriksson, Johan G;
- Giegling, Ina;
- Konte, Bettina;
- Roussos, Panos;
- Giakoumaki, Stella;
- Burdick, Katherine E;
- Payton, Antony;
- Ollier, William;
- Chiba-Falek, Ornit;
- Attix, Deborah K;
- Need, Anna C;
- Cirulli, Elizabeth T;
- Voineskos, Aristotle N;
- Stefanis, Nikos C;
- Avramopoulos, Dimitrios;
- Hatzimanolis, Alex;
- Arking, Dan E;
- Smyrnis, Nikolaos;
- Bilder, Robert M;
- Freimer, Nelson A;
- Cannon, Tyrone D;
- London, Edythe;
- Poldrack, Russell A;
- Sabb, Fred W;
- Congdon, Eliza;
- Conley, Emily Drabant;
- Scult, Matthew A;
- Dickinson, Dwight;
- Straub, Richard E;
- Donohoe, Gary;
- Morris, Derek;
- Corvin, Aiden;
- Gill, Michael;
- Hariri, Ahmad R;
- Weinberger, Daniel R;
- Pendleton, Neil;
- Bitsios, Panos;
- Rujescu, Dan;
- Lahti, Jari;
- Hellard, Stephanie Le;
- Keller, Matthew C;
- Andreassen, Ole A;
- Glahn, David C;
- Malhotra, Anil K;
- Lencz, Todd
- et al.
Published Web Location
https://pubmed.ncbi.nlm.nih.gov/30001766/Abstract
Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88) presented a critique of our recently published paper in Cell Reports entitled 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets' (Lam et al., Cell Reports, Vol. 21, 2017, 2597-2613). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, 2018, 229-237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from 'inflation in the FDR [false discovery rate]', as suggested by Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88), and are not 'more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence'.
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