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How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy
- Grimm, Max‐Joseph;
- Respondek, Gesine;
- Stamelou, Maria;
- Arzberger, Thomas;
- Ferguson, Leslie;
- Gelpi, Ellen;
- Giese, Armin;
- Grossman, Murray;
- Irwin, David J;
- Pantelyat, Alexander;
- Rajput, Alex;
- Roeber, Sigrun;
- Swieten, John C;
- Troakes, Claire;
- Antonini, Angelo;
- Bhatia, Kailash P;
- Colosimo, Carlo;
- Eimeren, Thilo;
- Kassubek, Jan;
- Levin, Johannes;
- Meissner, Wassilios G;
- Nilsson, Christer;
- Oertel, Wolfgang H;
- Piot, Ines;
- Poewe, Werner;
- Wenning, Gregor K;
- Boxer, Adam;
- Golbe, Lawrence I;
- Josephs, Keith A;
- Litvan, Irene;
- Morris, Huw R;
- Whitwell, Jennifer L;
- Compta, Yaroslau;
- Corvol, Jean‐Christophe;
- Lang, Anthony E;
- Rowe, James B;
- Höglinger, Günter U;
- Group, for the Movement Disorder Society‐endorsed PSP Study
- et al.
Published Web Location
https://www.ncbi.nlm.nih.gov/pubmed/?term=30884545No data is associated with this publication.
Abstract
Background
The Movement Disorder Society criteria for progressive supranuclear palsy define diagnostic allocations, stratified by certainty levels and clinical predominance types. We aimed to study the frequency of ambiguous multiple allocations and to develop rules to eliminate them.Methods
We retrospectively collected standardized clinical data by chart review in a multicenter cohort of autopsy-confirmed patients with progressive supranuclear palsy, to classify them by diagnostic certainty level and predominance type and to identify multiple allocations.Results
Comprehensive data were available from 195 patients. More than one diagnostic allocation occurred in 157 patients (80.5%). On average, 5.4 allocations were possible per patient. We developed four rules for Multiple Allocations eXtinction (MAX). They reduced the number of patients with multiple allocations to 22 (11.3%), and the allocations per patient to 1.1.Conclusions
The proposed MAX rules help to standardize the application of the Movement Disorder Society criteria for progressive supranuclear palsy. © 2019 International Parkinson and Movement Disorder Society.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.