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Childhood overweight and obesity and timing of puberty in boys and girls: cohort and sibling-matched analyses
Published Web Locationhttps://watermark.silverchair.com/dyaa056.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAoQwggKABgkqhkiG9w0BBwagggJxMIICbQIBADCCAmYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMM468UD-qpGuzHN0mAgEQgIICNwF1C7YbwA1ElGVfBHPDwFS1PNKRpRGonhNANsibPXpaXAN1x9yz6eSy7Vom0MIcwWqunpzGMfkfVHHLp7I6ehvZrpx2L4JmjfQABRKpuFHb-83Gy8ygPeMGPYcAG1wFFM2FpecV9MhgYIxoFHedu1dvg8HKbHA7Jmuua_32fw7rSVt6IW8OazGMic4B72Pg7NaVv3vKxg19O4sEFlFSYpmtgMxpaGRYHmpYtvtdOC5Yo5WBTHF41yXw1RQVoPXmI-JovqfnrMRs7j86KyBwU1UYw8iPHe1uySkrFsygdVSTw9NCSeoS-EJYG1EDOXQsO2LrkJWWkkai8oCWvGv6B7SHsq_PnXJnl8uiw_4aiDf94tlO85VOvi5i_2Jj_unna0wIOwHlLxYU4WoP2QzG-Z6UGouz6A1U0irbbRjCts8far4XOdPUNH-QIhWP2vKXX1vQr-jRjsvVOQOzKxjvMHrE3rP-ECUwXX1VJtrzHV_ti1y4FY4PwFONzFDnUWR99DGh6sP_bb9wOLcG1ldEJthomm5_mXTlWilzMD0e7tzgfgvpIRW05SVRiJ3ZsNAQSA6ydxXB2RTmutD0J0E9sl99lVaVvY531jrMaJf67MgoNCd1MfGsBuynBrGTXWjy2FaIYQ0DI6brJkYauiqAaGeatJ4dNjOn4gJ57wW8WgeYrBDxgvdzYyYQraSCgLnjAGSHx999wGU9Bv-JCEUSchxJ4EAl7m9TKOaO7DKVuIHX9jibHG4FNQ
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BackgroundEarly puberty is a risk indicator for adult diseases. Identification of modifiable causes of earlier puberty is, therefore, warranted. We estimate the association between childhood body mass index (BMI) and pubertal timing in a cohort study and in a sibling-matched study to adjust for unobserved time-stable confounders shared within families.
MethodsFor the cohort study, 11 046 of 22 439 (49%) invited children, born 2000-203, from the Danish National Birth Cohort (DNBC) had information on childhood BMI at 7 years and self-reported, half-yearly puberty information from 11 years on Tanner stages, menarche, voice break, first ejaculation, acne, and axillary hair. For the sibling-matched study, 1700 brothers and sisters were included among 86 820 live-born singletons from the DNBC.
ResultsChildhood overweight (85th ≤ BMI < 95th percentile) and obesity (BMI ≥ 95th percentile) were associated with earlier age attaining the pubertal milestones in a dose-dependent manner in boys and girls. When modelling all pubertal milestones simultaneously, the pubertal milestones were attained earlier in: overweight boys: -3.1 [95% confidence interval (CI): -4.5, -1.7] months, overweight girls: -5.5 (95% CI: -7.1, -3.9) months, obese boys: -3.5 (95% CI: -5.1, -2.0) months, obese girls: -5.2 (95% CI: -7.1, -3.4) months compared with normal weight (BMI < 85th percentile) children. In the sibling-matched study, higher BMI was associated with earlier age at attaining most pubertal milestones in girls, but only a tendency toward earlier pubertal timing was observed in boys.
ConclusionsChildhood overweight and obesity were associated with earlier pubertal timing even after adjustment for unobserved time-stable confounders shared within families.
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