Biological Systems & Engineering

eScholarship stats: Breakdown by Item for May through August, 2026

Item	Title	Total requests	Download	View-only	%Dnld
4j8893w1	Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging	1,078	84	994	7.8%
60s4z9wm	Tumour exosome integrins determine organotropic metastasis	798	344	454	43.1%
6xs6568m	Slot Blot Assay for Detection of R Loops	753	612	141	81.3%
5n75t404	Pre-metastatic niches: organ-specific homes for metastases	706	214	492	30.3%
9d4221mc	De novo DNA synthesis using polymerase-nucleotide conjugates	686	277	409	40.4%
2n42n48w	The Impact of Electric Fields on Processes at Electrode Interfaces	678	502	176	74.0%
9pm0x5mh	Machine learning for metabolic engineering: A review	648	353	295	54.5%
2mq4z3j6	Complete biosynthesis of QS-21 in engineered yeast	589	358	231	60.8%
7s7342wx	Evaluation of bacterial hosts for conversion of lignin-derived p-coumaric acid to 4-vinylphenol	573	60	513	10.5%
3799153s	33 Unresolved Questions in Nanoscience and Nanotechnology	481	142	339	29.5%
1gq1w12k	Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype	471	120	351	25.5%
2zw971kg	Metabolic engineering strategies for sesquiterpene production in microorganism	469	172	297	36.7%
9bk272nb	Evolution-guided tolerance engineering of Pseudomonas putida KT2440 for production of the aviation fuel precursor isoprenol	460	418	42	90.9%
77f5s184	The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	457	161	296	35.2%
3qf33012	Binary vector copy number engineering improves Agrobacterium-mediated transformation	453	296	157	65.3%
5ns091ht	Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Resolving the hot and ionized Universe through the Sunyaev-Zeldovich effect	446	303	143	67.9%
2hg7004n	Systematic assessment of long-read RNA-seq methods for transcript identification and quantification	437	349	88	79.9%
75g874b4	Biosystem design of Corynebacterium glutamicum for bioproduction	426	293	133	68.8%
9g36j1zs	Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies	424	286	138	67.5%
57g863q6	A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses	407	384	23	94.3%
6r99w1b4	Complete biosynthesis of cannabinoids and their unnatural analogues in yeast	404	154	250	38.1%
66k3m8h5	Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents	401	240	161	59.9%
2ww6f9d2	Complete genomic and epigenetic maps of human centromeres	389	130	259	33.4%
0f40r591	Recent Advances in the Use of Ionic Liquids and Deep Eutectic Solvents for Lignocellulosic Biorefineries and Biobased Chemical and Material Production	382	283	99	74.1%
43x013sh	Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus	379	327	52	86.3%
3939k3wv	Land Resources for Wind Energy Development Requires Regionalized Characterizations	377	249	128	66.0%
7294g81k	Heterochromatin: Guardian of the Genome	369	167	202	45.3%
6940v666	Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients	360	99	261	27.5%
87h7j1t3	Verazine biosynthesis from simple sugars in engineered Saccharomyces cerevisiae	352	217	135	61.6%
8dh7k2k4	The complex polyploid genome architecture of sugarcane	349	240	109	68.8%
6bz273tk	Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	345	214	131	62.0%
2zr0520r	Advanced pathways for hydrogen production: a collective view from a technical experts meeting	343	170	173	49.6%
71q1b4jn	A map of the rubisco biochemical landscape	343	242	101	70.6%
06n5h0nh	Hydrogen storage and geo-methanation in a depleted underground hydrocarbon reservoir	338	172	166	50.9%
2nx9f1fj	Thirdhand Smoke: New Evidence, Challenges, and Future Directions	338	169	169	50.0%
25s902m0	Microbial production of advanced biofuels	334	203	131	60.8%
46b3v6xc	Geroscience: Linking Aging to Chronic Disease	328	89	239	27.1%
4369p87c	Methane to bioproducts: unraveling the potential of methanotrophs for biomanufacturing	326	155	171	47.5%
6gk6f7js	Genetic variations and their interaction with thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice	326	204	122	62.6%
1ct062cx	Nitrogen Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing	323	199	124	61.6%
2jx454ms	Neurospora intermedia from a traditional fermented food enables waste-to-food conversion	322	197	125	61.2%
3q12x1gh	Perspectives for self-driving labs in synthetic biology	319	110	209	34.5%
8xg3g0x6	IMG/PR: a database of plasmids from genomes and metagenomes with rich annotations and metadata	312	271	41	86.9%
6dr6v4vg	Adsorptive recovery of volatile fatty acids from wastewater fermentation broth	309	45	264	14.6%
42k112z2	A genomic catalog of Earth’s microbiomes	308	223	85	72.4%
1dm2j12r	The tier system: a host development framework for bioengineering	306	59	247	19.3%
13g5b11t	A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi	304	247	57	81.3%
2pd1334b	From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence	299	92	207	30.8%
61r4c30v	Deconstruction of Woody Biomass via Protic and Aprotic Ionic Liquid Pretreatment for Ethanol Production	298	139	159	46.6%
3f52f72c	Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo	293	183	110	62.5%

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