Upton Sinclair’s novel The Jungle has been read as a critique of unfettered capitalism in the urban space of Chicago at the beginning of the twentieth century. This essay argues that this capitalist critique may gain further depth when read through the intersection between transnational American studies and medical humanities. Through the perspective of the Lithuanian character Jurgis Rudkus, the narrative turns on its head xenophobic claims of immigrants as a health menace to the US American nation. In so doing, it engages the field of medicine in two significant ways. It counters the claim that immigrants have no knowledge of hygiene by looking at white tables through immigrant eyes; and it critiques the fact that the US medical system has become inhumane in its increasing economization. Reading Sinclair’s novel in dialogue with historical studies of migration and contagion at the beginning of the twentieth century as well as with other naturalistic texts such as Frank Norris’s The Octopus, I suggest that The Jungle anticipates current debates about health care and health justice, as they have recently been addressed in Barack Obama’s autobiography A Promised Land.