In addressing the problem of invasive species, decision makers have a variety of options, each targeting different aspects as it evolves over time and space. We develop a 2-region bioeconomic model that includes several transmission pathways that spread the invader. Within each region, inspections, removal efforts, and sustainable land management practices, including habitat restoration and less damaging production activities, are available to the regulator. We investigate the implications of different transmission pathways and second-best policies on the control patterns and invasive populations. Second-best settings where certain controls are not available to the regulator result in large distortions on the optimal use of the land. Overall, we find that non-linear interactions between regions, pathways, and controls are significant determinants of the optimal management of invasive species.