In the hospital setting, the underlying causes of poor quality of patient care and the failures that jeopardize patient safety have resulted in catastrophic patient outcomes and dissatisfaction with safety systems among care providers. This quantitative study compared hospitalized patients' perceived experiences of care with the perceptions of patient safety culture among care providers. Two instruments in common use, the Consumers Assessment of Healthcare Providers and Systems-Hospital version (HCAHPS) and the Hospital Survey on Patient Safety Culture (HSOPSC) were statistically analyzed using a negative binomial regression model. Results demonstrated that several provider variables were significant predictors of patient outcomes on all six or five of six HCAHPS subscales including: Organizational learning and quality improvement, overall perceptions of safety, teamwork within the unit, staffing, supervisor and manager support for safety, and teamwork across units (p < .001). Research applications for this study include development of a model for comparing data from the two instruments and a framework for the examination of the forces that affect patient and provider perceptions of quality, care outcomes, and failures.