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Article
Peer Reviewed

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease

George, M Patricia;
Novelli, Enrico M;
Shigemura, Norihisa;
Simon, Marc A;
Feingold, Brian;
Krishnamurti, Lakshmanan;
Morrell, Matthew R;
Gries, Cynthia G;
Haider, Syed;
Johnson, Bruce A;
Crespo, Maria M;
Bhama, Jay K;
Bermudez, Christian;
Yousem, Samuel A;
Toyoda, Yoshiya;
Champion, Hunter C;
Pilewski, Joseph M;
Gladwin, Mark T

UC San Francisco Previously Published Works (2013)

Little is known about the use of lung transplantation in the management of sickle cell disease-associated pulmonary arterial hypertension (SCD-PAH). We present clinical and pathological data and report the first successful outcome of bilateral lung transplantation in a patient with severe SCD-PAH and pulmonary veno-occlusive disease (PVOD). We discuss the complexities of multidisciplinary planning and management of lung transplantation in patients with SCD-associated pulmonary vascular complications. This case reports the first documented successful lung transplant and first case of PVOD in a patient with SCD-PAH.

Cover page: First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease