This work briefly discusses the potential applications of the Skipper-CCD technology in astronomy and reviews its current use in dark matter and neutrino experiments. An overview of the ongoing efforts to build multi-kilogram experiments with these sensors is given, in the context of the Oscura experiment. First results from the characterization of Oscura sensors from the first 200 mm wafer-fabrication run with a new vendor are presented. The overall yield of the electron counting capability of these sensors is 71%. A noise of 0.087 e− RMS, with 1225 samples/pix, and a dark current of (0.031±0.013) e−/pix/day at 140 K were measured.