- Dude, Marie-Adrienne;
- Kaeppler, Ulrich;
- Herb, Monika;
- Schiller, Markus;
- Schulz, Franziska;
- Vedder, Birgit;
- Heppner, Saskia;
- Pradel, Gabriele;
- Gut, Jiri;
- Rosenthal, Philip J;
- Schirmeister, Tanja;
- Leippe, Matthias;
- Gelhaus, Christoph
A series of etacrynic acid derivatives was synthesized and screened for their in vitro activity against Plasmodium falciparum, as well as their activity against recombinantly expressed falcipain-2 and -3. The two most active compounds of the series displayed IC(50) values of 9.0 and 18.8 microM against Plasmodia.
