- Adelman, John P;
- Clapham, David E;
- Hibino, Hiroshi;
- Inanobe, Atsushi;
- Jan, Lily Y;
- Karschin, Andreas;
- Kubo, Yoshihiro;
- Kurachi, Yoshihisa;
- Lazdunski, Michel;
- Miki, Takashi;
- Nichols, Colin G;
- Palmer, Lawrence G;
- Pearson, Wade L;
- Sackin, Henry;
- Seino, Susumu;
- Slesinger, Paul A;
- Tucker, Stephen;
- Vandenberg, Carol A
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).