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Scholarly Works (1 results)

Article
Peer Reviewed

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

Degrado, William;
Rey-Carrizo, M;
Barniol-Xicota, M;
Ma, C;
Frigolé-Vivas, M;
Torres, E;
Naesens, L;
Llabrés, S;
Juárez-Jiménez, J;
Luque, FJ;
Degrado, WF

UC San Francisco Previously Published Works (2014)

Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogue