A crucial function of our goal-directed behavior is to select task-relevant targets among distractor stimuli, some of which may share properties with the target and thus compete for attentional selection. Here, by applying functional magnetic resonance imaging (fMRI) to a visual search task in which a target was embedded in an array of distractors that were homogeneous or heterogeneous along the task-relevant (orientation or form) and/or task-irrelevant (color) dimensions, we demonstrate that for both (orientation) feature search and (form) conjunction search, the fusiform gyrus is involved in processing the task-irrelevant color information, while the bilateral frontal eye fields (FEF), the cortex along the left intraparietal sulcus (IPS), and the left junction of intraparietal and transverse occipital sulci (IPTO) are involved in processing task-relevant distracting information, especially for target-absent trials. Moreover, in conjunction (but not in feature) search, activity in these frontoparietal regions is affected by stimulus heterogeneity along the task-irrelevant dimension: heterogeneity of the task-irrelevant information increases the activity in these regions only when the task-relevant information is homogeneous, not when it is heterogeneous. These findings suggest that differential neural mechanisms are involved in processing task-relevant and task-irrelevant dimensions of the searched-for objects. In addition, they show that the top-down task set plays a dominant role in determining whether or not task-irrelevant information can affect the processing of the task-relevant dimension in the frontoparietal regions.

One of the most firmly established factors determining the speed of human behavioral responses toward action-critical stimuli is the spatial correspondence between the stimulus and response locations. If both locations match, the time taken for response production is markedly reduced relative to when they mismatch, a phenomenon called the Simon effect. While there is a consensus that this stimulus-response (S-R) conflict is associated with brief (4-7 Hz) frontal midline theta (fmθ) complexes generated in medial frontal cortex, it remains controversial (1) whether there are multiple, simultaneously active theta generator areas in the medial frontal cortex that commonly give rise to conflict-related fmθ complexes; and if so, (2) whether they are all related to the resolution of conflicting task information. Here, we combined mental chronometry with high-density electroencephalographic measures during a Simon-type manual reaching task and used independent component analysis and time-frequency domain statistics on source-level activities to model fmθ sources. During target processing, our results revealed two independent fmθ generators simultaneously active in or near anterior cingulate cortex, only one of them reflecting the correspondence between current and previous S-R locations. However, this fmθ response is not exclusively linked to conflict but also to other, conflict-independent processes associated with response slowing. These results paint a detailed picture regarding the oscillatory correlates of conflict processing in Simon tasks, and challenge the prevalent notion that fmθ complexes induced by conflicting task information represent a unitary phenomenon related to cognitive control, which governs conflict processing across various types of response-override tasks.SIGNIFICANCE STATEMENT Humans constantly monitor their environment for and adjust their cognitive control settings in response to conflicts, an ability that arguably paves the way for survival in ever-changing situations. Anterior cingulate-generated frontal midline theta (fmθ) complexes have been hypothesized to play a role in this conflict-monitoring function. However, it remains a point of contention whether fmθ complexes govern conflict processing in a unitary, paradigm-nonspecific manner. Here, we identified two independent fmθ oscillations triggered during a Simon-type task, only one of them reflecting current and previous conflicts. Importantly, this signal differed in various respects (cortical origin, intertrial history) from fmθ phenomena in other response-override tasks, challenging the prevalent notion of conflict-induced fmθ as a unitary phenomenon associated with the resolution of conflict.