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Article
Peer Reviewed

Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis

Spinelli, Matthew A;
Lowery, Brentton;
Shuford, Jennifer A;
Spindler, Jon;
Kearney, Mary F;
McFarlane, Jenny R;
McDonald, Cheryl;
Okochi, Hideaki;
Phung, Nhi;
Kuncze, Karen;
Jee, Kathryn;
Johannessen, DeeJay;
Anderson, Peter L;
Smith, Dawn K;
Defechereux, Patricia;
Grant, Robert M;
Gandhi, Monica

UC San Francisco Previously Published Works (2021)

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

Cover page: Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis