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Scholarly Works (2 results)

Article
Peer Reviewed

HIV, Hepatitis B Virus, and Hepatitis C Virus Prevalence Among High-Risk Populations in South India

Dinesha, Thongadi Ramesh;
Boobalan, Jayaseelan;
Sivamalar, Sathasivam;
Solomon, Sunil S;
Poongulali, Selvamuthu;
Pradeep, Ambrose;
Murugavel, Kailapuri G;
Balakrishnan, Pachamuthu;
Smith, Davey M;
Saravanan, Shanmugam

UC San Diego Previously Published Works (2018)

Article
Peer Reviewed

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses

Saravanan, Shanmugam;
Gomathi, Selvamurthi;
Kausalya, Bagavathi;
Boobalan, Jayaseelan;
Murugavel, Kailapuri G;
Balakrishnan, Pachamuthu;
Mothi, Sarvode N;
Solomon, Sunil S;
Kumarasamy, Nagalingeswaran;
Selvamuthu, Poongulali;
Solomon, Suniti;
Smith, Davey M

UC San Diego Previously Published Works (2015)

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

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