We prove a Plancherel theorem for a nonlinear Fourier transform in two dimensions arising in the Inverse Scattering method for the defocusing Davey–Stewartson II equation. We then use it to prove global well-posedness and scattering in L2 for defocusing DSII. This Plancherel theorem also implies global uniqueness in the inverse boundary value problem of Calderón in dimension 2, for conductivities σ> 0 with log σ∈ H˙ 1. The proof of the nonlinear Plancherel theorem includes new estimates on classical fractional integrals, as well as a new result on L2-boundedness of pseudo-differential operators with non-smooth symbols, valid in all dimensions.