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Scholarly Works (1 results)

Article
Peer Reviewed

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

Criswell, Lindsey;
Chung, Sharon;
Manjarrez-Orduño, N;
Marasco, E;
Chung, SA;
Katz, MS;
Kiridly, JF;
Simpfendorfer, KR;
Freudenberg, J;
Ballard, DH;
Nashi, E;
Hopkins, TJ

UC San Francisco Previously Published Works (2012)

The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes. We identified an association of CSK with systemic lu