Our aim was to prospectively evaluate the relationship between low back pain-related disability and quantitative measures from [¹⁸F]-sodium fluoride ([¹⁸F]-NaF) MR imaging. Six patients with facetogenic low back pain underwent dynamic [¹⁸F]-NaF PET/MR imaging. PET metrics were correlated with clinical measures and MR imaging grading of lumbar facet arthropathy. A significant positive correlation was observed between maximum facet joint uptake rate and clinical disability (P < .05). These data suggest that dynamic [¹⁸F]-NaF PET may serve as a useful biomarker for facetogenic disability.