Macro-roughness elements such as boulders and bedrock outcrops, collectively referred to as large bed elements (LBEs), are key features influencing hydrodynamics and morphodynamics in mountain rivers. Where LBEs are abundant and account for a substantial portion of total flow resistance, existing geomorphic theory, previous physical experiments, and limited field observations support the theory that LBE configurations adjust to maximize flow resistance. However, methods to explicitly map individual features along entire river segments are lacking, thus limiting analysis of LBE spatial structure in boulder-bedded rivers. In addressing these gaps, this study sought to develop a procedure for mapping LBEs from 3D point-clouds, explore LBE spatial structure in a real boulder-bedded river, and test the hypothesis that LBE configurations were organized to maximize flow resistance. The mapping procedure applied a ground classification algorithm to produce a roughness surface model, from which LBEs were extracted by a marker controlled watershed algorithm. Implementing the procedure, 42,176 LBEs were mapped in 13.2-km of the mountainous Yuba River (Northern California). Scale and discharge-dependent LBE concentration and spacing metrics were quantified for multiple laterally and/or hierarchically nested spatial domains and classified to differentiate three flow-resistance based hydrodynamic regimes: isolated roughness, wake interference, and skimming flow. Of these regimes, wake interference corresponds to a state of maximum resistance, so hypothesis testing involved determining if this regime was dominant. Results confirmed 25 of 28 segment- and reach-scale LBE concentrations were in the wake interference regime. However, spacing metrics classified 24 of these same spatial domains in the skimming flow regime. Concentration metrics, which quantify LBE density in a given spatial area, differ from spacing metrics, which represent LBE proximity to one another. While comparison of segment and reach-scale regime classifications by each metric concluded concentration was superior to spacing for regime classification purposes, these disparities leave open questions about this extremal model of geomorphic adjustment. Lastly, lateral variability of metrics across the river corridor had implications for discharge-dependent resistance.