Spinal cord injuries (SCI) are devastating with no effective treatments and excessive medical costs. Placental mesenchymal stem cells (PMSCs) are a promising avenue of treatment due to their neuroprotective and angiogenic properties (Kumar, 2019). In addition, extracellular vesicles (EVs) released from these stem cells are an attractive cell-free therapeutic approach. Extracellular vesicles are approximately 150 nm vesicles released by placental mesenchymal stem cells that contain the proteins, miRNAs and other cargo of the cells themselves (Ramasubramanian 2019).