- Wang, Sinan;
- Korenchan, David E;
- Perez, Paola M;
- Taglang, Céline;
- Hayes, Thomas R;
- Sriram, Renuka;
- Bok, Robert;
- Hong, Andrew S;
- Wu, Yunkou;
- Li, Henry;
- Wang, Zhen;
- Kurhanewicz, John;
- Wilson, David M;
- Flavell, Robert R
Alterations in Zn2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn2+ is an area of active investigation. Herein, enriched [1-13 C]cysteine and [1-13 C2 ]iminodiacetic acid were developed as Zn2+ -specific imaging probes using hyperpolarized 13 C magnetic resonance spectroscopy. [1-13 C]cysteine was used to accurately quantify Zn2+ in complex biological mixtures. These sensors can be employed to detect Zn2+ via imaging mechanisms including changes in 13 C chemical shift, resonance linewidth, or T1 .