- Gilja, Vikash;
- Pandarinath, Chethan;
- Blabe, Christine H;
- Nuyujukian, Paul;
- Simeral, John D;
- Sarma, Anish A;
- Sorice, Brittany L;
- Perge, János A;
- Jarosiewicz, Beata;
- Hochberg, Leigh R;
- Shenoy, Krishna V;
- Henderson, Jaimie M
Neural prostheses have the potential to improve the quality of life of individuals with paralysis by directly mapping neural activity to limb- and computer-control signals. We translated a neural prosthetic system previously developed in animal model studies for use by two individuals with amyotrophic lateral sclerosis who had intracortical microelectrode arrays placed in motor cortex. Measured more than 1 year after implant, the neural cursor-control system showed the highest published performance achieved by a person to date, more than double that of previous pilot clinical trial participants.