- Armstrong, MJ;
- Naglie, G;
- Duff-Canning, S;
- Meaney, C;
- Gill, D;
- Eslinger, PJ;
- Zadikoff, C;
- Mapstone, M;
- Chou, KL;
- Persad, C;
- Litvan, I;
- Mast, BT;
- Fox, S;
- Tang-Wai, DF;
- Marras, C
Background/aims
The role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood.Methods
The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models.Results
Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not.Conclusion
The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies.