A salamander hatchling, Palaeoplethodon hispaniolae gen. n., sp. n. (Amphibia: Caudata), is described from Dominican Republic amber. While physical features align the fossil with members of the family Plethodontidae, the short forelimb with the foot lacking distinct digits and the long hind limb with elongated foot and strongly fused digits, as well as its presence in 15–40 mya Dominican amber, distinguish the fossil from previously described salamanders. The apparent 13–14 costal grooves and strongly webbed digits are characters shared with members of the extant plethodontid genus Bolitoglossa PETERS, 1879, the most speciose genus of Neotropical salamanders. This is the first salamander recovered from any amber source and the first undisputed salamander reported from the Caribbean region.