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Scholarly Works (1 results)

Article
Peer Reviewed

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies

Roose, Jeroen;
Cyster, Jason;
Daley, SR;
Coakley, KM;
Hu, DY;
Randall, KL;
Jenne, CN;
Limnander, A;
Myers, DR;
Polakos, NK;
Enders, A;
Roots, C

UC San Francisco Previously Published Works (2013)

Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoantib

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies