The HOMEChem (House Observations of Microbial and Environmental Chemistry) is a collaborative indoor air chemistry field study to be performed in June 2018 at the UTest House, a manufactured research house located in the University of Texas at Austin's research campus. The HOMEChem experiment investigates the effects of building occupants and their activities, such as cooking and cleaning, on the chemistry of the gas phase, particle phase, and surfaces in a simulated home environment. Specifically, this study focuses on the presence of organic species, chemical oxidants, and reactive nitrogen species indoors compared to outdoor levels. This study incorporates state-of the art atmospheric chemistry instrumentation from multiple research groups to build a shared dataset from those measurements.