This article examines how three literary narratives portraying the psychological effects of illness deal with issues of control in the doctor-patient-family relationship. Specifically explored are how patient, physician, and family members cope with the feelings of vulnerability and loss of control brought on by illness; and how each seeks to gain and maintain a sense of control in this coping process. Suggestions are offered for uses of these narratives in medical education. By exploring themes of control in the doctor-patient relationship, physicians develop greater insight and empathy that in turn can lead to improved outcomes for both patient and doctor.